Publications and Reports

Displaying 21 - 30 of 351
E.g., 17 Aug 2018
E.g., 17 Aug 2018
2 Sep 2015
Diabetes is increasing globally and lower extremity amputations (LEA) are complications of this condition. Depression is reported to be more common in people with diabetes, although the aetiology is multifactorial. The number of people being diagnosed with diabetes is increasing worldwide (estimated at 11%), but the impact of depression in this group on the risk of amputation is largely unknown.
1 Sep 2015

An increasing and often inappropriately large proportion of the resources and attention of the healthcare system is being diverted into the Emergency and Urgent Care System (EUCS).To describe the evolution of health policy relevant to EUCS in Ireland, using the Health Policy Triangle, to examine coherence between different policy documents and to assess implementation of these policies.Design: retrospective documentary analysis of current policy documents outlining the delivery of emergency a...

1 Sep 2015

The Health Service Executive has embarked on a series of regional system re-designs to change the organisation of urgent and emergency care delivery in Ireland.
Purpose of these programmes is to “develop integrated services across all stages of the care journey” with the goal of increasing efficiency and improving performance.

Planning documents identified by documentary analysis reveal emphasis on ‘hub and spoke’ models of care.
In re-designs carried out to...

12 Aug 2015

Isolated nocturnal hypertension (INH) is associated with greater mortality and cardiovascular events. Subclinical target organ damage (TOD) is a prognostic marker for cardiovascular events. Our objective is to systematically summarize evidence on the association between INH and subclinical TOD. Observational population studies were considered. INH was defined as nighttime blood pressure (BP) ⩾120 and/or 70 mm Hg with daytime BP <135/85 mm Hg. We systematically searched Pubmed, EMBASE and t...

12 Aug 2015



Glycated haemoglobin A1c (HbA1c) measurement is recommended as an alternative to fasting plasma glucose (FPG) for the diagnosis of pre-diabetes and type 2 diabetes. However, evidence suggests discordance between HbA1c and FPG. In this study we examine a range of metabolic risk features, pro-inflammatory cytokines, acute-phase response proteins, coagulation factors and white blood cell counts to determine which assay more accurately identifies individuals at i...

31 Jul 2015

Objective To test whether providing surgeons with peer benchmarked feedback about patient-reported outcomes is effective in improving patient outcomes.

Design Cluster randomised controlled trial.

Setting Secondary care—Ireland.

Participants Surgeons were recruited through the Irish Institute of Trauma and Orthopaedic Surgery, and patients were recruited in hospitals prior to surgery. We randomly allocated 21 surgeons and 550 patients.


22 Jul 2015

Mean corpuscular volume (MCV) is a measure of the average volume of red blood cells. The detection of an elevated MCV, termed macrocytosis (with or without anemia), often prompts an extensive and costly work-up for an underlying cause and/or referral to secondary care. Known determinants of macrocytosis listed in textbooks include vitamin B12 and folate deficiency, alcohol use (with or without associated liver disease), hemolysis, hypothyroidism, coeliac disease, drug use, and hematological c...

22 Jul 2015

An association between smoking and elevated MCV has been reported from a number of studies since the 1970s [1-3]. However, knowledge of this relationship, causal or otherwise, has not translated into clinical practice or been highlighted in any of the screening models for macrocytosis. In earlier research [4], which focused on the causes of hematinic deficiency in 1,207 Irish adults, we observed an unexpected independent association between smoking and macrocytosis. The current study examined...

15 Jul 2015

The aim of this study was to estimate the association between birth order and number of siblings with body composition in adolescents. Data are from a birth cohort study conducted in Pelotas, Brazil. At the age of 18 years, 4563 adolescents were located, of whom 4106 were interviewed (follow-up rate 81·3 %). Of these, 3974 had complete data and were thus included in our analysis. The variables used in the analysis were measured during the perinatal period, or at 11, 15 and/or 18 years of age....


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