"Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable disease, which is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Exacerbations and co-morbidities contribute to the overall severity in individual patients" (GOLD 2015). It is estimated that 65 million people worldwide have...
Health outcomes research has gained considerable traction over the past decade as the medical community attempts to move beyond traditional outcome measures such as morbidity and mortality. Since its inception in 2009, the BREAST-Q has provided meaningful and reliable information regarding health-related quality of life (HRQOL) and patient satisfaction for use in both clinical practice and research. In this study, we review how researchers have used the BREAST-Q and how it...
Laboratory testing is an integral part of day-to-day primary care practice, with approximately 30 % of patient encounters resulting in a request. However, research suggests that a large proportion of requests does not benefit patient care and is avoidable. The aim of this systematic review was to comprehensively search the literature for studies evaluating the effectiveness of interventions to improve primary care physician use of laboratory tests.Methods
A search of Pub...
No data regards lipoprotein particle profiles in obese and non-obese metabolic health subtypes exist. We characterised lipoprotein size, particle and subclass concentrations among metabolically healthy and unhealthy obese and non-obese adults.
Cross-sectional sample of 1834 middle-aged Irish adults were classified as obese (BMI ≥30 kg/m2) and non-obese (BMI <30 kg/m2). Metabolic health was defined using three metabolic health definiti...
Preconception maternal bereavement may be associated with an increased risk for infant mortality, although these previously reported findings have not been replicated. We sought to examine if the association could be replicated and explore if risk extended into childhood.
Using a Danish population-based sample of offspring born 1979 to 2009 (N = 1,865,454), we analyzed neonatal (0-28 days), postneonatal infant (29-364 days), and early childhood (1-5 y...
Burden of disease studies-crucial for informing public health policies.
Non-Communicable Diseases (NCDs) constitute the highest burden.
According to the WHO, 21% of the total Disability adjusted life years in 2012 in Ireland were from NCDs.
Comprehensive recent estimate of NCDs burden employing common metrics are not available for the Irish population.
Aims of the study:
To measure the burden of selected NCDs (ischemic heart disease, stro...
Overweight and obesity during pregnancy is associated with an increased risk of gestational diabetes mellitus (GDM), preeclampsia and macrosomia.
Antenatal lifestyle interventions have been shown to be effective in reducing these risks, however, studies often fail to identify the mechanisms by which the intervention is expected to be effective.
1. To identify the barriers and enablers to behaviour change from the perspective of overweight and obese pregnant women and...
Pre-Eclampsiais a pregnancy specific condition characterised by a significant rise in blood pressure (>140/90mmHg) and new onset proteinin the urine (>300mg in 24 hours) after 20 weeks gestation (1).
It accounts for 12% of maternal deaths per year globally (1), affecting 2-3% of all Irish pregnancies (2). Forthe mother it can lead to the development of long term morbidities, and increases the risk of future hospitalisation. Furthermore it can impact infant development by increasin...